Factors of Cell Degeneration or Death caused by Mutant Tau Protein

Tau protein is a microtubule associated mainly expressed in neurons. Under pathological conditions, abnormally hyperphosphorylated and separated from microtubules. Abnormal aggregates form nerve fiber tangles, which are insoluble the brain. It due to rupture caused by dysfunction it with neurofibrillar degeneration Alzheimer's disease.This paper studies several reports research on structure function of protein, role diseases its relationship neurodegenerative diseases. This concludes that has undergone abnormal modification aggregation many diseases, but specific type causes neurotoxicity, as well pathogenesis phosphorylation functional injury inducing apoptosis, still not fully understood. Various modifications occur under fatal cascade events at different stages neuron apoptosis. Therefore, effects cytotoxicity mediated very complicated. Different or even opposite conclusions sometimes drawn protein-mediated neurodegeneration studies. may be differences type, gene mutation expression level.